2nd International Conference on
Human Genetics and Genetic Disorders

Dimitrios P. Nikolelis received his PhD from University of Athens in 1976 and he is a professor of analytical and environmental chemistry in Department of Chemistry, University of Athens. Prof. Dimitrios Nikolelis has coordinated 3 European Projects on environmental biosensors (CIPA96-0231, IC15-CT96-0804 and QLK3-2000-01311). He also was twice a. NATO Director in the following Advanced Research Workshops: 1. Biosensors for Direct Monitoring of Environmental Pollutants in Field, Smolenice, Slovakia,: May 1996 and 2. Portable biosensors for the Rapid Detection of Biochemical Weapons of Terrorism, July 2012. Prof. Dimitrios Nikolelis has over 200 scientific papers in scientific journals and conferences. He is the Editor of 5 books on Biosensors (1. Biosensors for Direct Monitoring of Environmental Pollutants in Field, Springer, 1996, 2. Portable Chemical Sensors- Weapons against Bioterrorism, Springer, 2012 and 3. Portable Biosensing of Food Toxicants and Environmental Pollutants, CRC, 2013 3. 4. Biosensors for Security and Bioterrorism Applications, Springer, 2014. 5. Nanotechology and biosensors: recent advances, Elsevier, 2017. He is the Editor of many scientific journals. His research is targeted on the fabrication of portable biosensors for in the field uses and he has authored a large number of scientific papers on the detection of environmental pollutants such as hydrazines, dioxins, insecticides, toxins, etc. His current interests also include the construction of novel chemical nanosensors that can be used for the rapid detection of environmental pollutants directly in the gas phase. Prof. D. P. Nikolelis group has recently utilized graphene and ZnO to develop chemical nanosensors based on polymer lipid films for species of clinical or food significance such as urea, uric acid, cholesterol, etc. In progress, there is the evaluation and validation of nanosensors that are based on stabilized polymerized lipid films supported on glass fiber filters using a dry spot test using optical methods of analysis (i.e., fluorescence) to detect environmental pollutants such as insecticides, plant hormones, toxins, hydrazines, etc.

1. Biosensors for Direct Monitoring of Environmental Pollutants in Field, Smolenice, Slovakia,: May 1996 and 2. Portable biosensors for the Rapid Detection of Biochemical Weapons of Terrorism, July 2012. Prof. Dimitrios Nikolelis has over 200 scientific papers in scientific journals and conferences. He is the Editor of 5 books on Biosensors (1. Biosensors for Direct Monitoring of Environmental Pollutants in Field, Springer, 1996, 2. Portable Chemical Sensors- Weapons against Bioterrorism, Springer, 2012 and 3. Portable Biosensing of Food Toxicants and Environmental Pollutants, CRC, 2013 3. 4. Biosensors for Security and Bioterrorism Applications, Springer, 2014. 5. Nanotechology and biosensors: recent advances, Elsevier, 2017. He is the Editor of many scientific journals. His research is targeted on the fabrication of portable biosensors for in the field uses and he has authored a large number of scientific papers on the detection of environmental pollutants such as hydrazines, dioxins, insecticides, toxins, etc. His current interests also include the construction of novel chemical nanosensors that can be used for the rapid detection of environmental pollutants directly in the gas phase. Prof. D. P. Nikolelis group has recently utilized graphene and ZnO to develop chemical nanosensors based on polymer lipid films for species of clinical or food significance such as urea, uric acid, cholesterol, etc. In progress, there is the evaluation and validation of nanosensors that are based on stabilized polymerized lipid films supported on glass fiber filters using a dry spot test using optical methods of analysis (i.e., fluorescence) to detect environmental pollutants such as insecticides, plant hormones, toxins, hydrazines, etc.

Dr Ian James Martins is an Editor/Reviewer for Open Acess Pub/MDPI journals and various other international journals. Advisory Board Member for Photon Journal. Fellow of International Agency for Standards and Ratings (IASR). Conferred with the RICHARD KUHN RESEARCH AWARD-2015 ENDOCRINOLOGY AND METABOLISM. Chief Editor for International Journal of Diabetes Research (2014-2018), Research and Reviews: Neuroscience (2016-2018) and Journal of Diabetes and Clinical Studies (2017-2018). BIT Member (BIT Congress. Inc) with an h-index of 65, (ResearchGate STATs (28), Scopus Author ID: 7103152779/Mendeley STATS (21), UWA Research Repository (16). Scientist for The Science Advisory Board (USA) and an Academic with Academia.edu (220 Public Mentions). The citations past 27 years have accumulated to >4770. Ian James Martins - Semantic Scholar Profile https://www.semanticscholar.org/author/Ian-James-Martins/5258067. Semantic Scholar profile for Ian James Martins, with fewer than 133 highly influential citations RESEARCHGATE ANALYSIS: Ian J Martins | Ph D | Centre of Excellence for Alzheimer's Disease ...https://www.researchgate.net/profile/Ian_Martins2 under Ian James Martins’ name places publication Research Interest (1622) with an RG score (> 96%) of international SCIENTISTS. ORCID CONNECTING RESEARCHER: Editorial Team www.macrothink.org/journal/index.php/jfs/about/editorialTeamBio/13511 Editorial Team.

Anti-Aging, Global Health and Chronic Disease . Keywords: Anti-Aging Genes, Appetite, Environment, Nutrition, Senescence IMPACT OF PREVIOUS RESEARCH TO THE FIELD OF MEDICINE AND LABORATORY TECHNOLOGY THAT MAY AVOID INADVERTENT ERRORS AND MAY TRANSLATE TO COMMERCIALISATION OF MEDICAL RESEARCH THAT determines CRITICAL HEALTH OUTCOMES. Development of a BLOOD TEST has been of critical interest to the for metabolic disease with relevance to diabetes and neurodegenerative diseases. Interests in Biomarker Research has escalated with relevance to mitochondrial survival and organ disease in diabetes and Alzheimer’s disease. The global chronic disease epidemic is expected to cost Biomarker Research between 15 to 20 billion dollars in the next 20 years. Biomarkers such as Sirtuin 1 are now relevant to mitochondrial apoptosis versus mitochondrial biogenesis and may supersede the various biomarkers for mitochondrial survival relevant to diabetes, Alzheimer’s disease and neurodegenerative disease research

Name: Abyt Surname: Ibraimov Citizenship: Kyrgyz Republic (Kyrgyzstan) Current status: Head of Laboratory of Human Genetics, National Center of Cardiology & Internal Medicine, Education Diploma of higher education, pediatrician, Kyrgyz State Medical Institute, Frunze, Kyrghyzstan, 1964-1970. Postgraduate course. Institute of Medical Genetics, USSR Academy of Medicine, Moscow, USSR, 1970-1974. Ph.D., Institute of Medical Genetics, USSR Academy of Medicine, Moscow, USSR, December, 1974. Ph.D. thesis: "The fine morphology of C group chromosomes in human karyotype". Dr.Sc., Institute of Cytology and Genetics, Siberian Branch of USSR Academy of Sciences, Novosibirsk, USSR, 1985. Dr.Sc., theses: “Chromosomal polymorphism in human populations”.

1. Zakharov A.F., Baranovskaya L.I., Ibraimov A.I., Benjush V.A., Demintseva V.S. and Oblapenko N.S. 1974. Differential spiralization along mammalian mitotic chromosomes. II. 5-bromdeoxyuridine and 5-bromdeoxycitidine revealed differentiation in human chromosome. Chromosoma, 44: 343-359. 2. Ibraimov А.I. and Mirrakhimov M.M. 1979. PTC-testing ability in populations living in Kyrghyzia with special reference to hypersensitivity: its relation tо sex and age. Hum. Genet., 46: 97-105. 3. Mirrakhimov M.M. and Ibraimov A.I. 1982. Physiological and certain genetic mechanisms of adaptation of native populations to the high altitude climate of Pamir and Tien-Shan. Proc. Indian Statistical Inst. Golden Jubilee. Intern. Conf. of Human Genetics and Adaptation. Calcutta. p. 81-84. 4. Ibraimov А.I., Mirrakhimov М.М., Nazarenko S.А., Axenrod Е.I. and Akbanova G.А. 1982. Нuman chromosomal polymorphism. I. Chromosomal Q-polymorphism in Mongoloid populations of Central Asia. Hum. Genet., 60: 1-7. 5. Ibraimov А. I. and Mirrakhimov М. М. 1982. Human chromosomal polymorphism. II. Chromosomal С-polymorphism in Mongoloid populations of Central Asia. Hum. Genet., 60: 8-9. 6. Ibraimov А. I. and Mirrakhimov М. М. 1982. Human chromosomal polymorphism. III. Chromosomal Q-polymorphism in Mongoloids of Northern Asia. Hum. Genet., 62: 252-257. 7. Ibraimov А. I. and Mirrakhimov М. М. 1982. Human chromosomal polymorphism. IV. Q-polymorphism in Russians living in Kirghizia. Hum. Genet., 62: 258-260. 8. Ibraimov А. I. and Mirrakhimov М. М. 1982. Human chromosomal polymorphism. V. Chromosomal Q-polymorphism in African populations. Hum. Genet., 62: 261-265. 9. Ibraimov А. I. and Mirrakhimov М. М. 1983. Human chromosomal polymorphism. VI. Chromosomal Q-polymorphism in Turkmen of the Kara-Kum Desert of Central Asia. Hum. Genet., 63: 380-383. DOI: 10.1111/j.1399-0004.1983.tb00077.x 10. Ibraimov А. I. 1983. Human chromosomal polymorphism. VII. The distribution of chromosomal Q-polymorphic bands in different human populations. Hum. Genet., 63: 384-391. 11. Ibraimov А.I. 1983. Chromosome preparations of human whole lymphocytes - an improved technique. Clin. Genet., 24: 240-242. 12. Ibraimov A.I. and Mirrakhimov M.M. 1985. Chromosomal polymorphism in human populations living in different ecological zones of Africa and Eurasia. Ann. Hum. Biol., 12(6): 552-553. 13. Ibraimov А. I. and Mirrakhimov М. М. 1985. Q-band polymorphism in the autosomes and the Y chromosome in human populations. In: “Progress and Topics in Cytogenetics. The Y chromosome. Part А. Basic characteristics of Y chromosome”. А. А. Sandberg (Ed). Alan R. Liss, Inc., New York. USA, pp. 213-287. 14. Ibraimov A.I. 1986. Chromosomal Q-heterochromatin regions in human populations living in various climatogeographic conditions. Proc. 7th Intern. Congress of Human Genetics, Western Berlin, p. 183. 15. Ibraimov А.I., Mirrakhimov М.М. and Aksenrod E.I. 1986. Human chromosomal polymorphism. VIII. Chromosomal Q Polymorphism in the Yakut of Eastern Siberia. Hum. Genet., 73: 147-150. 16. Ibraimov А. I., Mirrakhimov М. М., Axenrod Е. I. and Kurmanova G.U. 1986. Human chromosomal polymorphism. IX. Further data on the possible selective value of chromosomal Q-heterochromatin material. Hum. Genet., 73: 151-156. 17. Ibraimov A.I. 1990. Distribution of relative chromosomal Q-variant frequencies in human populations. Abst. Int. Assoc. of Human Biologists Conf. on Isolation and Migration, Fukui, Japan, p. 63. 18. Ibraimov А. I., Kurmanova G. U., Ginsburg Е. К., Aksenovich T. I. and Axenrod Е. I. 1990. Chromosomal Q-heterochromatin regions in native highlanders of Pamir and Tien-Shan and in newcomers. Cytobios, 63: 71-82. 19. Ibraimov А. I., Axenrod Е. 1., Kurmanova G. U. and Turapov О.А. 1991. Chromosomal Q-heterochromatin regions in the indigenous population of the Northern part of West Siberia and in new migrants. Cytobios, 67: 95-100. 20. Ibraimov A.I. 1991. Cerumen phenotypes in certain populations of Eurasia and Africa. Am. J. Phys. Anthropol., 84: 209-211. 21. Ibraimov А. I. 1993. The origin of modern humans: а cytogenetic model. Нum. Evol., 8(2): 81-91. 22. Ibraimov А.I., Sachkova L.M., Kurmanova G.U. and Axenrod E.I. 1993. Transferrine subtypes in some Eurasian and African populations. Нum. Hered., 43 (1): 3-57. 23. Ibraimov AI, Karagulova GO, Kim EY. 1997. Chromosomal Q-heterochromatin regions in indigenous populations of the Northern India. Ind. J. Hum. Genet. 3: 77-81. 24. Ibraimov А.I, Karagulova G.О. and Kim Е.Y. 2000. The relationship between the Y chromosome size and the amount of autosomal Q-heterochromatin in human populations. Cytobios, 102: 35-53. 25. Ibraimov A.I. 2003. Condensed chromatin and cell thermoregulation. Complexus, 1: 164-170. 26. Ibraimov A.I. 2004. The origin of condensed chromatin, cell thermoregulation and multicellularity. Complexus, 2: 23-34. 27. Ibraimov A.I. and Karagulova G.O. 2006. Chromosomal Q-heterochromatin regions in individuals of various age groups. Int. J. Hum. Genet., 6(3): 219-228. 28. Ibraimov A.I. and Karagulova G.O. 2006. Chromosomal Q-heterochromatin variability in neonates deсeased during first year of age. Int. J. Hum. Genet., 6(4): 281-285. 29. Ibraimov A.I. and Tabaldiev S.K. 2007. Condensed chromatin, cell thermoregulation and human body heat conductivity. J. Hum. Ecol., 21(1): 1-22. 30. Ibraimov A.I. 2007. The evolution of body heat conductivity, skin and brain size in human. J. Hum. Ecol., 21(2): 95-103 31. Ibraimov A.I. 2007. Genetic adaptation of man. In: Anthropology today: trends, scope and applications. Bhasin V, Bhasin MK, (eds). Kamla-Raj Enterprises, Delhi, India, pp. 513-523. 32. Ibraimov A.I. 2008. On the pathogenesis of atherosclerosis: the role of the blood temperature, phase transitions of lipoproteins and turbulence of blood flow. J. Hum. Ecol., 23(3): 195-201. 33. Ibraimov A.I. 2008. Possible mechanism of the sex differentiation and its artificial regulation. Int. J. Hum. Genet., 8(3): 283-290. 34. Ibraimov A.I. 2009. Noncoding DNAs and origin of sex. Int. J. Hum. Genet., 9(1): 39-47. 35. Ibraimov A.I. 2009. Darwin’s gemmules and development. Anthropologist, 11(1): 1-5. 36. Ibraimov A.I. 2010a. Noncoding DNAs in Development and Evolution. In: MK Bhasin, C Susanne (Eds.): Anthropology Today: Trends and Scope of Human Biology. Delhi: Kamla-Raj Enterprises, pp. 199- 224. 37. Ibraimov A.I. 2010b. Chromosomal Q-heterochromatin regions in populations and human adaptation. In: MK Bhasin, C Susanne (Eds.): Anthropology Today: Trends and Scope of Human Biology. Delhi: Kamla- Raj Enterprises, pp. 225-250. 38. Ibraimov A.I., A.K. Kazakova, I.K. Moldotashev, M.T. Sultanmuratov and K.S. Abdyev 2010a. Variability of Human Body Heat Conductivity in Population. I. Methodological and Theoretical Approaches. J. Hum. Ecol. 32(1): 1-22. 39. Ibraimov, A.I., A.K. Kazakova, I.K. Moldotashev, M.T. Sultanmuratov and K.S. Abdyev. 2010b. Variability of Human Body Heat Conductivity in Population. II. Diseases of Civilization.J. Hum. Ecol. 32(2): 69-78. 40. Ibraimov A.I. Origin of modern humans: а cytogenetic model. Hum. Evol., 2011, 26(1-2): 33-47. 41. Ibraimov A.I. 2011. Evolution without genes. Int. J. Genet., 3(1): 50 – 61. 42. Ibraimov A.I. 2012. On the origin of sex. GJSFR (C), 12(8) (Ver. 1.0), 1-6. [Global Journal of Science Frontier Research: C Biological Sciences]. 43. Ibraimov A.I. 2012. Evolution of human skin color and thermoregulation. Int. J. Genet., 4(3), 111-115. 44. Ibraimov A.I., Akanov A.A., Meymanaliev T.S., Karakushukova A.S., Kudrina N.O., Sharipov K.O., Smailova R.D. 2013. Chromosomal Q-heterochromatin polymorphisms in 3 ethnic groups (Kazakhs, Russians and Uygurs) of Kazakhstan. Int. J.Genet., 5(1), 121-124. 45. Ibraimov A.I. 2013. Is it Possible Artificial Sex Regulation in Mammals? Global Journal of Science Frontier Research Bio-Tech and Genetics, Vol. 13, Issue 2, Version 1.0, pp. 23-29. 46. Ibraimov A.I. 2014. Chromosomal Q-heterochromatin and sex in human population. J. Mol. Biol. Res., vol. 4, No. 1, 10-19. 47. Ibraimov A.I., Akanov A.A., Meymanaliev T.S., Smailova R.D., Baygazieva G.D.2014. Chromosomal Q-heterochromatin and age in human population. J. Mol. Biol. Res., vol. 4, No. 1, 1-9. 48. Ibraimov A.I., Akanov A.A., Meimanaliev T.S., Sharipov K.O., Smailova R.D., Dosymbekova R. 2014. Human Chromosomal Q-heterochromatin Polymorphism and Its Relation to Body Heat Conductivity. Int. J. Genet., 6(1), 142-148. 49. Ibraimov A.I. 2015. Heterochromatin: The visible with many invisible effects. Global Journal of Medical Research (C), Volume 15, Issue 3, Version 1.0, pp. 7-32. 50. Ibraimov A.I. 2015. Darwin’s Gemmules and Adaptation. J. Adv. Biol.,Vol.8, No.2., pp. 1589-1595. 51. Ibraimov A.I. 2015. The Evolution of Material Basis of Evolution. J. Adv. Biol., Vol. 8, No. 2, pp. 1596-1607. 52. Ibraimov A.I. 2016. Methodical Approaches to the Study of Human chromosomal Q-Heterochromatin Variability. J. Mol. Biol. Res., Vol. 6, No. 1, pp. 1-10. 53. Ibraimov A.I. 2016. Why only people and apes are ill with common cold? The possible role of chromosomal Q-heterochromatin. J. Mol. Biol. Res., Vol. 6, No. 1, pp. 11-19. 54. Ibraimov AI (2016) Chromosomal Q-Heterochromatin Polymorphism in Patients with Alimentary Obesity. Biol. Med. (Aligarh), 8: 275. DOI: 10.4172/0974-8369.1000275 55. Ibraimov A.I. (2016) Chromosomal Q-heterochromatin Regions in Alcoholics and Drug Addicts. Biol. Med. (Aligarh), 8:346. DOI: 10.4172/0974-8369.1000346 56. Ibraimov A.I. (2017) Cell Thermoregulation: Problems, Advances and Perspectives. J. Mol. Biol. Res., 7(1): 58-79. doi:10.5539/jmbr.v7n1p58 57. Ibraimov A.I. (2017) From 48 to 46 chromosomes: Origin of Man. J. Mol. Biol. Res., Vol. 7, No. 1, pp. 80-87. doi:10.5539/jmbr.v7n1p80 58. Ibraimov A.I. (2017). Chromosomal Q-Heterochromatin and Atherosclerosis. J.Mol. Biol.Res., Vol. 7, No. 1; 2017. doi:10.5539/jmbr.v7n1p143 59. Ibraimov A.I. 2018. Possible Mechanism of Sex Determination in Mammals. J. Mol. Biol. Res. Vol. 8, No. 1; 48-52. doi:10.5539/jmbr.v8n1p48 60. Ibraimov A.I. 2018. Why do not all people Ill with High-Altitude Pulmonary Edema? Journal of Cardiology & Diagnostics Research, 1(1): 13-18. 61. Ibraimov A.I. 2018. Human Body Heat Conductivity in norm and pathology: A review. Advance Research Journal of Multidisciplinary Discoveries. 32(3)pp.12-21. 62. Ibraimov A.I. 2018. Chromocenters and Cell Thermoregulation. J Biol Med Res. Vol.2 No.3:19. 63. Ibraimov А.I. 2019. Human adaptation: why only genes? Int J Biol Med. 1: 22-33. 64. Ibraimov A.I. 2019. The origin of modern humans. What was primary: genes or heterochromatin? Hum Evol, Vol. 34, No. 1-2, 39-58. 65. Ibraimov A.I. 2019. Chromosomal Q-heterochromatin Polymorphism and Sport. Int J Biol Med. 1: 45-52. 66. Ibraimov A.I. 2019. X-chromosome inactivation: dosage compensation of genes or heterochromatin?. Int J Biol Med. 1: 75-87. 67. Ibraimov A.I. 2019. Cell Thermoregulation: Reality or just a logical Construction?. Int J Biol Med. 1: 65-74. 68. Ibraimov A.I. 2019. B-chromosomes and cell thermoregulation. Int J Biol Med. 1: 99-106. 69. Ibraimov A.I. 2019. Sex determination and Y chromosome constitutive heterochromatin. Current Research in Biochemistry and Molecular Biology, 1(1) 1-5. http://dx.doi.org/10.33702/crbmb.2019.1.1.1 70. Ibraimov A.I. 2019. Cell thermoregulation hypothesis: its origin, material basis, mechanisms and meaning. Int J Biol Med. 1: 114-123.

Prof. Sarantuya Jav graduated from Medical University of Sankt Petersburg (Leningrad), Russia with a bachelor’s degree in medicine, as a paediatrician. In 1998, she holds a master’s degree at the Medical University of Mongolia. In 2004, she received her PhD degree in Medicine at the School of Medicine, Kagoshima University, Japan. She became an associate professor of HSUM in 2009 and professor of MNUMS in 2014.

Molecular Biology and Genetics