Biography:
Prof. Sarantuya Jav graduated from Medical University of Sankt Petersburg (Leningrad), Russia with a bachelor’s degree in medicine, as a pediatrician. In 1998, she held master’s degree at the Medical University of Mongolia. In 2004, she received her PhD degree in Medicine at the School of Medicine, Kagoshima University, Japan. She became associate professor of HSUM in 2009 and professor of MNUMS in 2014.
From 1988 – 1999, she worked at Department of infantry and department of reanimation of National Center for Child and Maternity Health. 1999 – 2004, she was a doctorate and assistant teacher at the Pediatric department. 2004 to present, she is working at the Dept. of Molecular biology and Genetics, School of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences as a lecturer, senior lecturer, Ass. Professor and Professor. Now prof. Sarantuya is a head of Dept. of Molecular Biology and Genetics.
Prof. Sarantuya Jav teaches Molecular Biology, Biotechnology and Applied molecular biology and diagnostics for undergraduate, graduate and postgraduate students.
Abstract:
Age-related macular degeneration (AMD) is an eye condition, that occurs people aged above 50, leads to gradual loss of the vision because of damage in the macula, which is located in the center of the retina. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibility. Therefore, we investigated the association between rs833061 polymorphism of VEGF-A gene and rs10490924 polymorphism of ARMS2 gene and AMD. This case-control study was conducted on 74 AMD patients and 32 unaffected age- and gender-matched control individuals. Genomic DNA was extracted from the peripheral venous blood. The single nucleotide polymorphisms were identified by restriction fragment length polymorphism (RFLP) method and results confirmed by gel electrophoresis. No significant differences were observed for С allele and СС genotype frequency of rs833061 polymorphism of VEGF-A gene between patients and controls. However, analysis of rs10490924 polymorphism of ARMS2 gene shows that T allele (OR=2.72, 95% CI, 1.47 – 5.02, p=0.001), TT genotype (OR=4.54, 95% CI, 1.49 – 13.87,p=0.019) were significantly associated with AMD risk. Haplotype analysis of these SNPs showed that C+T haplotype was statistically significantly different (OR=5.23, 95% CI, 1.76-15.54, p=0.002) between patients and controls. As shown by results, rs10490924 polymorphism of ARMS2 gene show that T allele, TT genotype and C+T haplotype were significantly associated with AMD risk.